Disulfiram is used to help overcome your drinking problem
Disulfiram medication is an alcohol antagonist, prescribed for chronic alcoholism. It blocks the processing of alcohol in the body.
Mechanism of action :
Produces irreversible inhibition of the enzyme responsible for oxidation of the ethanol metabolite acetaldehyde. The resultant accumulation of acetaldehyde may be responsible for most of the signs and symptoms occurring after ethanol ingestion in disulfiram-treated patients. The hypotensive response may be due to inhibition of norepinephrine synthesis by the major disulfiram metabolite diethyldithiocarbamate.
Contraindications :
Contraindicated in patients with severe heart disease, mental disorder, who are taking alcohol containing preparations and hypersensitivity.
Dosage & When it is to be taken :
Adult: PO- 800 mg as a single dose on the 1st day. Reduce dose by 200 mg/day.
Maintenance: 100-200 mg/day. It comes as a tablet to take by mouth, with or without food.
Warnings and Precautions :
Caution should be exercised in patients with history of diabetes, thyroid disease, epilepsy, brain damage, kidney or liver disease, any allergy, who are taking other medications, during pregnancy and breastfeeding.
It may cause drowsiness, do not drive a car or operate machinery while taking this medication.
Avoid alcohol consumption.
Monitor liver function and complete blood cell counts regularly while taking this medication.
Side effects :
If you experience any of the following serious side effects, stop taking disulfiram and seek emergency medical attention :
• an allergic reaction (swelling of your lips, tongue, or face; shortness of breath; closing of your throat; or hives);
• seizures;
• extreme tiredness;
• dark urine;
• yellowing of the skin or eyes (jaundice);
• large appetite changes;
• weakness, dizziness or loss of coordination; or
• severe diarrhea or vomiting.
Storage Conditions :
Store it at room temperature (20° to 25°C) and in an airtight container. Protect from moisture and heat. Keep away from reach of children.
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